Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)

OCS, whether prescribed intermittently or long term, affect BEC distribution potentially leading to heightened risk of phenotype misclassification and influencing subsequent treatment decisions. FeNO appears to be less susceptible to OCS-induced suppression. Disease burden was high for those in the LTOCS group and was high independent of dose and BEC. Our findings highlight the importance of considering OCS use, even intermittent use, when characterizing SA, and suggests the need for earlier phenotyping and alternative treatment strategies for LTOCS patients with low BEC.

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Publication Details

Journal
World Allergy Organization Journal
Published
2025-06-03
DOI
https://doi.org/10.1016/j.waojou.2025.101066
Citations
3
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
3.49

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article

Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)

Lakmini Bulathsinhala, Piotr Kuna, Asger Sverrild, Breda Cushen et al.
3 citations
World Allergy Organization Journal
Asthma and respiratory diseases
3.49
article

Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)

Lakmini Bulathsinhala, Piotr Kuna, Asger Sverrild, Breda Cushen, Matthew Peters, Guy Brusselle, Riyad Al‐Lehebi, Camille Taillé, Martín Sívori, Mariko Siyue Koh, Tatsuya Nagano, Andriana Ι. Papaioannou, Liam Gabriel Heaney, Fernando Saldarini, Mohit Bhutani, Dóra Lúðvíksdóttir, Konstantinos Exarchos, Wenjia Chen, Carlos Andrés Celis Preciado, Ruth Murray, Njira Lucia Lugogo, Athena Gogali, Sinthia Bosnic‐Anticevich, Chau‐Chyun Sheu, Kirsty Fletton, Florence Schleich, Mohsen Sadatsafavi, Hao‐Chien Wang, Michael P. Makris, Jorge Fernando Maspero, Philip G. Bardin, Flavia Hoyte, Renaud Louis, Giorgio Walter Canonica, Eve Denton, Dermot Ryan, Chin Kook Rhee, Libardo Jiménez-Maldonado, Zsuzsanna Csoma, Delbert R. Dorscheid, John W. Upham, Michael E. Wechsler, Kenneth R. Chapman, George Christoff, Désirée Larenas‐Linnemann, John Townend, Peter G. Gibson, Todor A. Popov, ARNAUD AB BOURDIN, Rebecca Gall, Petros Bakakos, Christian Taube, Francesca Puggioni, Peter G. Middleton, Ghislaine Scélo, Christine Jenkins, Alan Altraja, Ana María Stok, Celine Goh, José Alberto Ferreira, Eileen Wang, Sverre Lehmann, Leif Hilding Bjermer, David Price, Paula Kauppi, Susanne Hansen, Giuseppe Guida, Charlotte Suppli Ulrik, Paul Pfeffer, Laila Salameh, Céline Bergeron, Stelios Loukides, Anne Chèvremont, Κonstantinos Κostikas, Victoria Carter, Andréanne Côté, Borja G. Cosío, Hyonsoo Joo, Jeffrey Shi Kai Chan, Unnur Steina Björnsdóttir, Mona Al‐Ahmad, M. Diane Lougheed, Carlos A. Torres‐Duque, Simon Couillard, Lyle Melenka, Rohit Katial, Vidya V. Navaratnam, Paulo Márcio Pitrez, Enrico Heffler, Belinda Cochrane, Ming‐Ju Tsai, Luis Pérez de Llano, Pin‐Kuei Fu, Celeste Porsbjerg, John Blakey, Adeeb A. Bulkhi, Takashi Iwanaga, João Fonseca, Iván Solarte, Lauri Lehtimäki, Roy A. Pleasants, Cláudia Chaves Loureiro, Mark Hew, Aaron Beastall, Nikolaos G. Papadopoulos, Pujan H. Patel, Zhixiao Wang, Bassam Mahboub, Diahn‐Warng Perng, Anahí Yáñez, Bernt Bøgvald Aarli, David J. Jackson, Wei‐Han Cheng, Ledit Ardusso, Elvia Angelica Contreras Contreras, Aggelos Ladias, Shelley Abercromby, Bellanid Rodríguez-Cáceres
article en
3 citations

Abstract

OCS, whether prescribed intermittently or long term, affect BEC distribution potentially leading to heightened risk of phenotype misclassification and influencing subsequent treatment decisions. FeNO appears to be less susceptible to OCS-induced suppression. Disease burden was high for those in the LTOCS group and was high independent of dose and BEC. Our findings highlight the importance of considering OCS use, even intermittent use, when characterizing SA, and suggests the need for earlier phenotyping and alternative treatment strategies for LTOCS patients with low BEC.

World Allergy Organization JournalVol. 18(7)
Reykjavík University (IS), University of Copenhagen (DK), Queen's University Belfast (GB), National University of Tucumán (AR), Camden and Campbelltown Hospitals (AU), Centre National de la Recherche Scientifique (FR), University of Helsinki (FI), Humanitas University (IT), Alfaisal University (SA), Université de Sherbrooke (CA), Vancouver Coastal Health (CA), University of British Columbia (CA), National Yang Ming Chiao Tung University (TW), Kaohsiung Medical University (TW), University of Alberta (CA), Inserm (FR), Universidad de La Sabana (CO), University of Liège (BE), The University of Queensland (AU), University of Iceland (IS), National University of Singapore (SG), Queen Mary University of London (GB), Tampere University (FI), National Taiwan University (TW), The University of Western Australia (AU), King's College London (GB), University of Toronto (CA), Regeneron (United States) (US), Lund University (SE), University of Ioannina (GR), University of Aberdeen (GB), Université de Montpellier (FR), Umm al-Qura University (SA), Universidade de Santiago de Compostela (ES), National and Kapodistrian University of Athens (GR), Queen's University (CA), Université Paris Cité (FR), Curtin University (AU), Singapore General Hospital (SG), Barts Health NHS Trust (GB), Pontificia Universidad Javeriana (CO), University of Michigan (US), Vancouver Hospital and Health Sciences Centre (CA), Concord Repatriation General Hospital (AU), Helsinki University Hospital (FI), John Hunter Hospital (AU), Santa Casa Hospital (BR), Haukeland University Hospital (NO), Kingston General Hospital (CA), Rashid Hospital (AE), Woolcock Institute of Medical Research (AU), Frederiksberg Hospital (DK), Ghent University Hospital (BE), Beaumont Hospital (IE), King Fahd Medical City (SA), Bispebjerg Hospital (DK), Erasmus MC (NL), Hospitais da Universidade de Coimbra (PT), Sir Charles Gairdner Hospital (AU), Tartu University Hospital (EE), Copenhagen University Hospital (DK), Kaohsiung Medical University Chung-Ho Memorial Hospital (TW), Vancouver General Hospital (CA), Taipei Veterans General Hospital (TW), Westmead Hospital (AU), University of Manchester (GB), University of Sharjah (AE), Medical University of Sofia (BG), National Jewish Health (US), Kuwait University (KW), National University of Rosario (AR), Hunter Medical Research Institute (AU), Ruhrlandklinik (DE), Taichung Veterans General Hospital (TW), Center for Clinical Research and Prevention (DK), Centre Hospitalier Universitaire de Montpellier (FR), Kindai University Hospital (JP), Royal Brompton Hospital (GB), Assistance Publique – Hôpitaux de Paris (FR), Lung Institute (US), Hospital Médica Sur (MX), Hospital Ramos Mejía (AR), University Hospital St. Ivan Rilski (BG), ENT and Allergy (US), National University Hospital of Iceland (IS), The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR), AstraZeneca (Australia) (AU), Sanofi (United States) (US), St. Mary's Hospital (US), Observational & Pragmatic Research Institute (SG), Fundación Neumológica Colombiana (CO), Monash Health (AU), Medical University of Lodz (PL), Health Research Institute of the Balearic Islands (ES), Tampere University Hospital (FI), Centro Científico Tecnológico - Tucumán (AR), Ministry of Health (KW), National Taiwan University Hospital (TW), Tampere University (FI), Hospital Donación Francisco Santojanni (AR), Centre Hospitalier Universitaire de Liège (BE), Centre for Health Technology and Services Research (PT), Skåne University Hospital (SE), University of Palermo (AR), University General Hospital Attikon (GR), Centro Hospitalar de Vila Nova de Gaia (PT), University Hospital of Ioannina (GR), Mexfam (MX), Respiratory Clinical Trials (AU), Hospital Universitario Lucus Augusti (ES), Emissions Reduction Alberta (CA), Vancouver Coastal Health Research Institute (CA), National University Health System (SG), Hospital Universitario San Ignacio (CO), Dubai Medical College (AE), Favaloro Foundation (AR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), IRCCS Humanitas Research Hospital (IT), Alfred Health (AU), Országos Korányi Tbc és Pulmonológiai Intézet (HU), Université Laval (CA), University of Bergen (NO), University of Turin (IT), University of Tartu (EE), Monash University (AU), Western Sydney University (AU), Kobe University (JP), Athens State University (US), University of Coimbra (PT), Catholic University of Korea (KR), Institute for Social Security and Services for State Workers (MX), Erasmus University Rotterdam (NL), University of Colorado Denver (US), University of Edinburgh (GB), Macquarie University (AU)
Cystic Fibrosis Foundation, American Thoracic Society, Amgen, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Gilead Sciences, Teva Pharmaceutical Industries, United Therapeutics Corporation, Chiesi Farmaceutici, Danone, Helsingin Yliopisto, Université Laval, CSL Behring, European Respiratory Society, Universidad Nacional de Rosario, Regeneron Pharmaceuticals, Canadian Thoracic Society, Celltrion Healthcare, Kindai University, National Jewish Health, Covis Pharma, Government of Ontario, Cerecor, British Columbia Lung Association, Mylan, Allergy Therapeutics, Optimum Patient Care, Incyte, Kanazawa University, Celltrion, Moderna, Horizon Therapeutics, Glenmark Pharmaceuticals, Insmed, University of Alberta, Canadian Lung Association, Michael Smith Health Research BC, National Institute for Health and Care Research, King's College London, Queen's University Belfast, University of Aberdeen, Hunter Medical Research Institute, Macquarie University, Thoracic Society of Australia and New Zealand, Singapore General Hospital, University of New South Wales, Monash University, University of Queensland, Curtin University of Technology, Asthma Australia, Catholic University of Korea, Shanghai Educational Development Foundation, Erasmus Medisch Centrum, Lunds Universitet, Kuwait Foundation for the Advancement of Sciences, Queen's University, Universitair Ziekenhuis Gent, University of Toronto, Landspítali Háskólasjúkrahús, Novo Nordisk, Shire, Universiteit Gent, Universitetet i Bergen, National and Kapodistrian University of Athens, AstraZeneca Australia, University of British Columbia, Universidad de Buenos Aires, Háskóli Íslands, Shionogi, Uniwersytet Łódzki, Università degli Studi di Torino, Universidade do Porto, Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado, Vancouver Coastal Health Research Institute, Universidad del Rosario, Humanitas University, Pontificia Universidad Javeriana, Taichung Veterans General Hospital, Stiftung Universitätsmedizin Essen, Haukeland Universitetssjukehus, Tays, Skånes universitetssjukhus, King Fahad Medical City, Taipei Veterans General Hospital, Swedish Orphan Biovitrum, Orient Europharma, Bispebjerg Hospital, Grifols, Centro de Investigação em Tecnologias e Serviços de Saúde, Western Sydney University, Alfaisal University, Lung Health Foundation, Humanitas Research Hospital, Seqirus, Directorate for Biological Sciences, Genentech, Novartis Pharmaceuticals UK Limited, Sanofi Genzyme, Canadian Institutes of Health Research, Medical Research Council, Seoul St. Mary's Hospital, Catholic University of Korea, Faculty of Medicine and Health, University of Sydney, College of Medicine, Catholic University of Korea, UCB Pharma, Daiichi Sankyo Europe
Openalex Percentile: Top 8%
Asthma and respiratory diseases
3.49
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