Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics
Our work provides the first systematic analyses of transgenerational gene and chromatin dynamics following prenatal exposure to BPA or BPS. These results suggest that prenatal exposure to environmentally relevant doses of BPA or BPS alters chromatin accessibility and transcription factor motif activities, consequently contributing to disrupted transcriptional levels in neonatal spermatogonia, and some are sustained to F3 generations, ultimately leading to the reduction of sperm counts in adults. https://doi.org/10.1289/EHP16981.
Authors
- James A. MacLean (ORCID: https://orcid.org/0000-0003-3061-150X)
- Nathan C. Law (ORCID: https://orcid.org/0000-0003-4934-7892)
- Mingxin Shi (ORCID: https://orcid.org/0000-0003-3390-8827)
- Kanako Hayashi (ORCID: https://orcid.org/0000-0002-5028-799X)
- Liang Zhao (ORCID: https://orcid.org/0000-0003-2446-5577)
- Sarayut Winuthayanon (ORCID: https://orcid.org/0000-0002-8439-0389)
Institutions
- Nanjing Agricultural University (CN)
- Washington State University (US)
- University of Missouri (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1289/ehp16981
- Citations
- 3
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 3.60
Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences