Clinical and Immunological Features of a Large DiGeorge Syndrome Cohort
CD4 lymphopenia was more common than CD8 lymphopenia. Normal/high CD8 + and NK cell counts were remarkable. Increased CD8+ TEMRA cells seem to indicate peripheral homeostatic proliferation following viral infections. Low serum IgA correlated with low RTE% and impaired T-cell function. DGS severity markers include hypocalcemia, congenital cardiac anomaly, and T-cell lymphopenia.
Authors
- Pelin Özlem Şimşek‐Kiper (ORCID: https://orcid.org/0000-0001-7244-7766)
- Gülen Eda Ütine (ORCID: https://orcid.org/0000-0001-6577-5542)
- İlhan Tezcan (ORCID: https://orcid.org/0000-0001-7257-4554)
- Deniz Çağdaş (ORCID: https://orcid.org/0000-0003-2213-4627)
- Merve Kaşıkçı (ORCID: https://orcid.org/0000-0003-3211-2093)
- Merve Süleyman (ORCID: https://orcid.org/0000-0003-2128-5781)
Institutions
- Hacettepe University Hospital (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1007/s10875-025-01884-0
- Citations
- 3
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Hacettepe Üniversitesi