KidsBrainIT: Visualization of the Impact of Cerebral Perfusion Pressure Insult Intensity and Duration on Childhood Brain Trauma Outcome
The pediatric CPP dose-response on poor outcome was visualized successfully for the first time. Because the "critical" lower CPP limit exceeds the current recommended minimum CPP target for pediatric TBI treatments, there is an urgent need to validate childhood CPP dose-response to provide evidence-based CPP clinical targets in the future.
Authors
- Tsz-Yan Milly Lo (ORCID: https://orcid.org/0000-0003-0701-6534)
- Julian Zipfel (ORCID: https://orcid.org/0000-0003-4725-713X)
- Mireia Garcia Cusco (ORCID: https://orcid.org/0000-0003-0185-4705)
- James Weitz
- Maria Antonia Poca (ORCID: https://orcid.org/0000-0002-3831-0536)
- Bart P. Depreitere (ORCID: https://orcid.org/0000-0002-7458-0648)
- Bavo Kempen (ORCID: https://orcid.org/0000-0001-5326-4761)
- Stefano Pezzato (ORCID: https://orcid.org/0000-0003-0921-0875)
- Şt. M. Iencean (ORCID: https://orcid.org/0000-0002-6230-8540)
- Roddy O’Kane
- Arta Bārzdiņa (ORCID: https://orcid.org/0000-0002-2877-891X)
- Gayathri Subramanian (ORCID: https://orcid.org/0000-0003-1771-4002)
- Ian Piper (ORCID: https://orcid.org/0000-0003-1434-6347)
- Patricia A. Jones
Institutions
- Royal Hospital for Children (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Istituto Giannina Gaslini (IT)
- Bristol Royal Hospital for Children (GB)
- John Radcliffe Hospital (GB)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Children's Clinical University Hospital (LV)
- Hospital de Sabadell (ES)
- University Children's Hospital Tübingen (DE)
- Vall d'Hebron Hospital Universitari (ES)
- Royal Manchester Children's Hospital (GB)
- University of Edinburgh (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Neurocritical Care
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1007/s12028-025-02296-z
- Citations
- 3
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Alder Hey Children's NHS Foundation Trust
- University of Oxford
- European Commission
- University of Nottingham
- University of Bristol
- Fonds Wetenschappelijk Onderzoek
- Fundació Institut de Recerca Hospital Universitari Vall d’Hebron
- Medical Research Council
- St. George's, University of London