Effectiveness and safety of vitamin D use in pediatric practice

The review article presents data from modern studies confirming the multifaceted effect of vitamin D in the human body. Aim - to summarize the scientific literature regarding the efficacy and safety of vitamin D use in pediatric practice. It has been proven that receptors for the vitamin are present in most organs and tissues of the body. This confirms the importance of vitamin D not only in the processes of bone formation, but also in many of its extra-skeletal effects. Vitamin D affects the modulation of cell growth, neuromuscular conduction, has an anti-inflammatory effect, and is also an important stimulator of innate immunity due to the synthesis of antimicrobial peptides. Many studies have shown that vitamin D deficiency is characteristic of most children with respiratory infections and allergic diseases. Good preventive and therapeutic efficacy of vitamin D in acute and recurrent respiratory diseases, bronchial asthma, atopic dermatitis, allergic rhinitis and other pathological conditions in children and good tolerability of vitamin D have been revealed. To obtain the effect of vitamin D use, serum 25(OH)D concentrations should be maintained above 30-40 ng/ml (75-100 nmol/l). The use of Detrimax® is considered beneficial due to its safety profile (absence of harmful additives such as benzyl alcohol, emulsifiers, stabilizing agents, etc.); high bioavailability (thanks to its oil-based formulation); user convenience (pump dispenser and small capsule size); and a wide dosage range, which is important for individualized treatment in clinical settings. The authors declare no conflict of interest.