Analysis of the amount of endothelin-1 in children with haemostatic disorders induced by herpetic infections depending on severity and activity of the disease

In herpes infections, the virus actively interacts with the immune system, leading to an inflammatory response. This reaction can stimulate the formation of endothelin-1, which in turn can increase inflammation and lead to microcirculatory disorders, increased inflammation and increased risk of complications. Aim - to analyse the content of endothelin-1 in children with haemostatic disorders induced by herpes infections, depending on the severity and activity of the disease. Materials and methods. 100 children aged 0-18 years with haemostatic disorders induced by herpetic infections were examined at the onco-haematological department of the Vinnytsia Regional Children's Clinical Hospital of the Vinnytsia Regional Council. For comparison purposes, 40 practically healthy children were examined. In addition to general clinical examinations, all subjects underwent C-reactive protein, interleukin (IL)-1 and IL-6, endothelin-1, and polymerase chain reaction for Herpes Simplex (HSV) 1, HSV2, Cytomegalovirus, Epstein-Barr virus, Human Herpesvirus (HHV) 6, HHV 7 and HHV 8. Results. The level of endothelin-1 in children with haemostatic disorders induced by herpes infection was significantly higher than in healthy children. It was also noted that endothelin-1 levels were significantly (p≤0.05) higher in patients with vasopathy compared to those with thrombocytopenia and thrombocytosis. It was found that children with HSV 1 and 2 had significantly higher levels of endothelin-1 in the range (40.81-64.40)% compared with other agents. The presence of a positive moderate correlation between certain indicators of inflammatory process activity and endothelin-1 levels was revealed. Conclusions. Determination of endothelin-1 level may be one of the indicators of severity and activity of the pathological process, as well as a future target in the treatment and prevention of haemostatic disorders induced by herpetic infections in children. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee for all participants. Informed consent was obtained from patients (parents of children or their guardians). The authors declare no conflict of interest.