STC1 promotes paclitaxel resistance in oral squamous cell carcinoma by inhibiting oxidative stress via activating the JAK/STAT signaling pathway
This study identifies the STC1-STAT3-SLC7A11 axis as a key regulator of resistance to oxidative stress in OSCC, highlighting STC1 as a promising therapeutic target to overcome chemoresistance and improve outcomes in PTX-based therapies.
Authors
- Fan Ye (ORCID: https://orcid.org/0000-0002-1089-1498)
- Chao Feng (ORCID: https://orcid.org/0000-0002-6363-0021)
- Yanju Gong (ORCID: https://orcid.org/0000-0002-1672-5837)
- Mingfeng Li (ORCID: https://orcid.org/0000-0003-3472-9070)
- Min Liu (ORCID: https://orcid.org/0000-0002-8077-0130)
- Yanhong Li (ORCID: https://orcid.org/0009-0001-6231-0560)
- Xiaomeng Li (ORCID: https://orcid.org/0000-0003-1105-8083)
- Hao Liu (ORCID: https://orcid.org/0000-0002-5181-7024)
- Chuan Qin (ORCID: https://orcid.org/0000-0002-5354-8630)
- Xinghan Wu (ORCID: https://orcid.org/0000-0002-3716-2770)
- Yanfeng Xu (ORCID: https://orcid.org/0000-0003-0947-7254)
- Yalan Lu
- Lin Jiang
- Binbin Li (ORCID: https://orcid.org/0000-0003-4185-4208)
Institutions
- King University (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1016/j.lfs.2025.123787
- Citations
- 2
- Primary Topic
- Physiological and biochemical adaptations
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality