Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light
This work utilizes tailored – Cu 2 O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 o C with a size of 8.10 nm resulted in a 99.98% reduction of MRSA, 99.78% of Klebsiella pneumoniae , and 98.92% of SARS-CoV Delta within one minute under visible light. Cu 2 O QDs efficiently reduced 99.25% viability of 4T1 cancer cells in 15 min while maintaining more than 85% viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu 2 O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.
Authors
- Shao‐Yang Hu (ORCID: https://orcid.org/0000-0001-8809-3827)
- Sigit Tri Wicaksono (ORCID: https://orcid.org/0000-0003-3346-0989)
- SUTARSIS sutarsis
- Febriyansyah Saputra (ORCID: https://orcid.org/0009-0002-6855-3106)
- Azzah Dyah Pramata (ORCID: https://orcid.org/0000-0002-4868-3547)
- Agung Purniawan
- Farhan Aryo Hutomo
- Paundra Rizky Pratama (ORCID: https://orcid.org/0000-0003-2308-836X)
- Taras Geonovive De Yenarosa
- Revianny Nidom
Institutions
- University of Surabaya (ID)
- National Pingtung University of Science and Technology (TW)
- Sepuluh Nopember Institute of Technology (ID)
- Nanyang Technological University (SG)
- Universitas Airlangga (ID)
- Kumamoto University (JP)
Publication Details
- Journal
- Case Studies in Chemical and Environmental Engineering
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1016/j.cscee.2025.101248
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Badan Riset dan Inovasi Nasional
- Kementerian Riset dan Teknologi /Badan Riset dan Inovasi Nasional