Factors Associated with Multidrug-Resistant Tuberculosis in Patients Diagnosed in the Centre Region, Burkina Faso, 2020-2022

<i>Introduction:</i> The emergence of multidrug-resistant tuberculosis (MDR-TB) is a challenge for disease control and prevention worldwide. Objective: To study factors associated with MDR-TB in patients diagnosed in the Centre region, from 2020 to 2022. <i>Methods:</i> We conducted a retrospective unpaired case-control study on data from January 1, 2020 to December 31, 2022. The variables used were grouped into sociodemographic, clinical, paraclinical and therapeutic characteristics. We calculated crude and adjusted odds ratios (aOR) at a 95% confidence interval (CI), with a significance level ɑ= 5%. <i>Results:</i> Factors associated with multidrug-resistant tuberculosis were history of TB treatment [OR=7.36; p=<0.0001]; place of residence [OR=6.04; p=0.0001]; alcohol consumption [OR=4.20, p=0.002]; Acid-Fast Bacillus (AFB) ≥ 3+ [OR=3.37, p=0.008]; hospitalization during treatment [OR=5.20; IC95%=1.79, p=0.002]; DOTS knowledge [OR=6.53; p=<0.0001]. <i>Conclusion:</i> Our study identified several factors associated with multidrug-resistant tuberculosis, those related to behavior in both patients and caregivers being: history of TB treatment; alcohol consumption; and lack of knowledge of the DOTS strategy. Which means that future studies should aim to understand the impact of patient behavior/knowledge or caregiver attitudes so that the results can guide the use of scarce resources to optimize their impact.