Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study
This proteome-wide Mendelian randomization study offers a comprehensive molecular landscape of CRC, identifying GREM1, DKKL1, CHRDL2, and TMEM132A as potential therapeutic targets. Our research provides a critical foundation for future experimental validation and therapeutic development in colorectal cancer management.
Authors
- Jinsheng Ye
- Menghua Wu (ORCID: https://orcid.org/0000-0003-0459-3723)
- Zhen-Kun Pan
- Shi H (ORCID: https://orcid.org/0000-0002-9958-9892)
- Quan-Li Geng
- Yong-Jian Ni
Institutions
- Capital Medical University (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12014-025-09545-5
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.94