Loss of <scp>CXCR5</scp> expression and monocyte epithelial–mesenchymal transition are blood‐borne signatures of sterile granulomatous diseases

We have identified both shared and specific phenotypes in TU and sarcoidosis. Marked CXCR5 down-regulation occurs in active TU and could explain the unique absence of lymphadenopathy. Both TU and sarcoidosis are characterised by inflammatory monocyte phenotypes and transcriptional signatures of EMT.

Authors

Yuwei Hao (ORCID: https://orcid.org/0000-0003-3932-3686)
Matthew Cook (ORCID: https://orcid.org/0000-0002-3331-9363)
Anthea Anantharajah
Lyndell L. Lim (ORCID: https://orcid.org/0000-0003-2491-685X)
Gary Chew
Jane M. Wells
Anthony Hall

Institutions

Australian National University (AU)
The University of Melbourne (AU)
University of Cambridge (GB)
Wellington Hospital (NZ)
The Alfred Hospital (AU)
Canberra Hospital (AU)
The Royal Victorian Eye & Ear Hospital (AU)
Centre for Eye Research Australia (AU)
Monash University (AU)

Publication Details

Journal: Clinical & Translational Immunology
Published: 2025-01-01
DOI: https://doi.org/10.1002/cti2.70039
Primary Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Health and Medical Research Council

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article

Loss of CXCR5 expression and monocyte epithelial–mesenchymal transition are blood‐borne signatures of sterile granulomatous diseases

Yuwei Hao, Matthew Cook, Anthea Anantharajah, Lyndell L. Lim et al.

Jan 1, 2025

Clinical & Translational Immunology

Neutrophil, Myeloperoxidase and Oxidative Mechanisms

article

Loss of CXCR5 expression and monocyte epithelial–mesenchymal transition are blood‐borne signatures of sterile granulomatous diseases

Yuwei Hao, Matthew Cook, Anthea Anantharajah, Lyndell L. Lim, Gary Chew, Jane M. Wells, Anthony Hall

January 1, 2025article en

Abstract

We have identified both shared and specific phenotypes in TU and sarcoidosis. Marked CXCR5 down-regulation occurs in active TU and could explain the unique absence of lymphadenopathy. Both TU and sarcoidosis are characterised by inflammatory monocyte phenotypes and transcriptional signatures of EMT.

Clinical & Translational ImmunologyVol. 14(6)

Australian National University (AU), The University of Melbourne (AU), University of Cambridge (GB), Wellington Hospital (NZ), The Alfred Hospital (AU), Canberra Hospital (AU), The Royal Victorian Eye & Ear Hospital (AU), Centre for Eye Research Australia (AU), Monash University (AU)

National Health and Medical Research Council

Openalex Percentile: Top 86%

Neutrophil, Myeloperoxidase and Oxidative Mechanisms

DOI Open Access PDF OpenAlex

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Loss of <scp>CXCR5</scp> expression and monocyte epithelial–mesenchymal transition are blood‐borne signatures of sterile granulomatous diseases — Yuwei Hao, Matthew Cook, et al. · Clinical & Translational Immunology (2025) | TGRS Research Map | TGRS