Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms
This study provides new insights into the pathogenesis of IBD by elucidating the role of microtubules in epithelial barrier disruption. Our findings propose microtubule-modulating therapeutics as a potential novel treatment strategy for IBD, highlighting the importance of stabilizing microtubules to restore epithelial integrity and reduce inflammation.
Authors
- Xin‐hua Liang (ORCID: https://orcid.org/0000-0003-0718-3658)
- Lanlan Geng
- Xinghua Pan (ORCID: https://orcid.org/0000-0002-7421-8155)
- Sitang Gong (ORCID: https://orcid.org/0000-0002-6899-0616)
- Wanfu Xu (ORCID: https://orcid.org/0009-0009-4747-459X)
- Shuping Xie
- Fangying Yang
- Zhibin He (ORCID: https://orcid.org/0000-0001-8235-300X)
Institutions
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12964-025-02264-2
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangzhou Institute of Pediatrics, Guangzhou Women and Childrens Medical Center
- Guangzhou Municipal Science and Technology Project