Single-cell epigenomic and transcriptomic analysis unveils the pivotal role of GATA5/ISL1+ fibroblasts in cardiac repair post-myocardial infarction
The study provides novel perspectives on the mechanisms of myocardial injury and repair at the single-cell level and indicates the potential role of GATA5 and ISL1 as therapeutic targets for MI treatment.
Authors
- Shuchen Zhang (ORCID: https://orcid.org/0000-0001-8560-0045)
- Boyang Xiang (ORCID: https://orcid.org/0009-0007-7584-9390)
- Lili Chen (ORCID: https://orcid.org/0000-0003-0026-4877)
- Wenjing Wang (ORCID: https://orcid.org/0000-0002-4527-1168)
- Xiang Zhou
- Yiheng Zhao
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1093/cvr/cvaf101
- Citations
- 3
- Primary Topic
- Cardiac Structural Anomalies and Repair
- Type
- article
- Field-Weighted Citation Impact
- 6.02