Platelets and inflammation—insights from platelet non-coding RNA content and release in the Bruneck study and the PACMAN-AMI trial
Inflammation and leucocyte-derived RNAs in isolated platelets are associated with reduced platelet responses ex vivo, potentially reflecting exhaustion through pre-activation in vivo. We show that protein-bound ncRNAs are readily released from platelets, whereas vesicle-bound ncRNAs are preferentially retained. We highlight the potential of ncRNAs as biomarkers complementing aggregometry.
Authors
- Temo Barwari (ORCID: https://orcid.org/0000-0003-2279-8677)
- Christian Hengstenberg (ORCID: https://orcid.org/0000-0002-8284-2994)
- Jonas Häner (ORCID: https://orcid.org/0000-0002-1420-8967)
- Peter Willeit (ORCID: https://orcid.org/0000-0002-1866-7159)
- Clemens Gutmann (ORCID: https://orcid.org/0000-0003-0675-8632)
- Manuel Mayr (ORCID: https://orcid.org/0000-0002-0597-829X)
- Christian Cassel (ORCID: https://orcid.org/0000-0002-6051-632X)
- Timothy D. Warner (ORCID: https://orcid.org/0000-0003-3988-4408)
- Christian Schulte (ORCID: https://orcid.org/0000-0002-2643-7345)
- Peter Santer (ORCID: https://orcid.org/0000-0001-6878-5375)
- Bhawana Singh (ORCID: https://orcid.org/0000-0002-5834-8320)
- Lorenz Räber (ORCID: https://orcid.org/0000-0003-0824-3026)
- Johann Willeit (ORCID: https://orcid.org/0000-0003-4083-0466)
- Stefan Kiechl (ORCID: https://orcid.org/0000-0002-9836-2514)
- Kaloyan Takov (ORCID: https://orcid.org/0000-0002-8642-6306)
- Gonca Suna (ORCID: https://orcid.org/0000-0002-4024-2974)
- Paul C. Armstrong (ORCID: https://orcid.org/0000-0003-0904-677X)
- Melissa V. Chan (ORCID: https://orcid.org/0000-0003-2154-1386)
- Konstantinos Theofilatos (ORCID: https://orcid.org/0000-0001-6799-0553)
- Yasushi Ueki (ORCID: https://orcid.org/0000-0003-4630-9815)
Institutions
- Semmelweis University (HU)
- University of Bern (CH)
- Innsbruck Medical University (AT)
- Universität Hamburg (DE)
- Queen Mary University of London (GB)
- King's College London (GB)
- Universität Innsbruck (AT)
- University of Cambridge (GB)
- University Hospital of Bern (CH)
- British Heart Foundation (GB)
- Heart Foundation (US)
- Krankenhaus Bruneck (IT)
- Lung Institute (US)
- Zurich Heart House (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
- Imperial College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1093/cvr/cvaf100
- Citations
- 3
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.16