Voxtalisib inhibits enterovirus 71 replication by downregulating host RAN and restoring IFN–STAT signaling
RAN is a novel antiviral host target that indirectly mediates EV71 replication by regulating the nuclear-cytoplasmic transport of p-STAT1/2. Voxtalisib effectively restores IFN-STAT signaling by modulating RAN, offering a promising host-directed antiviral strategy against enteroviruses.
Authors
- WU Cheng-yuan
- Delong Wang (ORCID: https://orcid.org/0000-0002-8019-9691)
- Qian Wang (ORCID: https://orcid.org/0000-0002-2149-384X)
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-9655-7828)
- Han Yang (ORCID: https://orcid.org/0000-0002-4531-093X)
- Chaolin Huang (ORCID: https://orcid.org/0000-0001-6240-7963)
- Dingyu Zhang
- Zhengnan Li (ORCID: https://orcid.org/0000-0002-0450-1473)
- Qingyu Yang (ORCID: https://orcid.org/0000-0002-1525-2900)
- Xu Congrui (ORCID: https://orcid.org/0009-0009-9225-4086)
- Zhu Guangyan (ORCID: https://orcid.org/0000-0002-7381-4094)
- Xujuan Hu
- Long Gangyu
Institutions
- University of Science and Technology of China (CN)
- Union Hospital (HK)
- Jinyintan Hospital (CN)
- The People's Hospital Tongling (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jare.2025.05.053
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78