Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure
Elevated sICAM-1 levels were associated with poor outcomes in two separate cohorts of ARDS and ARF patients. Network analysis revealed sICAM-1 as a central hub, characterized by high centrality metrics. These findings underscore the multifaceted role of sICAM-1 in leukocyte transmigration, inflammation, and endothelial dysfunction and highlight its critical role in ARDS pathophysiology.
Authors
- Michelle Lim (ORCID: https://orcid.org/0000-0003-0311-8832)
- Angela C. Zeigler
- Michael S. D. Agus (ORCID: https://orcid.org/0000-0001-6454-6828)
- Jane Whitney
- Arunima Bera
- Colin J. Sallee (ORCID: https://orcid.org/0000-0002-2834-2657)
- Pratik Sinha (ORCID: https://orcid.org/0000-0003-3751-9079)
- Lucia Chen (ORCID: https://orcid.org/0000-0002-0380-7112)
- Michael A. Matthay (ORCID: https://orcid.org/0000-0003-3039-8155)
- Anil Sapru (ORCID: https://orcid.org/0000-0003-1528-8249)
- Daniela Markovic (ORCID: https://orcid.org/0009-0003-7128-280X)
- Matt S. Zinter (ORCID: https://orcid.org/0000-0003-3351-3278)
- Andreas Schwingshackl (ORCID: https://orcid.org/0000-0002-5608-0199)
- Arham Ali
Institutions
- Boston Children's Hospital (US)
- Apple (Israel) (IL)
- American College of Chest Physicians (US)
- University of California, Los Angeles (US)
- Washington University in St. Louis (US)
- Cardiovascular Institute Hospital (JP)
- Los Angeles Medical Center (US)
- UCSF Benioff Children's Hospital (US)
- UC Davis Children's Hospital (US)
- Loma Linda University Children's Hospital (US)
- Core Laboratories (United States) (US)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1097/ccm.0000000000006719
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71