Oral-gut axis in inflammation: periodontitis exacerbates ulcerative colitis via microbial dysbiosis and barrier disruption
Periodontitis may exacerbate UC by increasing harmful gut bacteria, reducing beneficial bacteria, and promoting the secretion of pro-inflammatory cytokines, thereby disrupting the intestinal barrier and worsening UC severity.
Authors
- Bin Chen (ORCID: https://orcid.org/0000-0001-8690-1835)
- Jinping Yu
- Tracy Y. Zhu (ORCID: https://orcid.org/0000-0002-0500-0865)
- Jinglu Lyu (ORCID: https://orcid.org/0000-0002-9784-1660)
- Qing Liu (ORCID: https://orcid.org/0000-0003-3173-9492)
- Harry Hua‐Xiang Xia (ORCID: https://orcid.org/0000-0002-7952-9200)
- Lili Li (ORCID: https://orcid.org/0000-0002-7272-9023)
- Yang Li (ORCID: https://orcid.org/0000-0002-6515-4567)
Institutions
- Nanjing University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12903-025-06269-8
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Nanjing University