Visualizing fatigue mechanisms in non-communicable diseases: an integrative approach with multi-omics and machine learning
This study provides preliminary insights into the potential involvement of alterations in lipid metabolism, catecholamine biosynthesis disruptions, microbial imbalances, and specific genetic variants in fatigue in patients with NCDs. These findings lay the groundwork for personalized interventions, although further validation and model refinement across diverse populations are needed to enhance the prediction performance and clinical applicability.
Authors
- Akira Fujiwara (ORCID: https://orcid.org/0009-0009-2892-3775)
- Hajime Takase (ORCID: https://orcid.org/0000-0001-5813-1386)
- Shoichi Ishida (ORCID: https://orcid.org/0000-0002-5638-3579)
- Hiromichi Wakui (ORCID: https://orcid.org/0000-0001-8023-922X)
- Yuichiro Yano
- Masayoshi Sakakura (ORCID: https://orcid.org/0000-0003-3649-3276)
- Kengo Azushima (ORCID: https://orcid.org/0000-0002-5136-0730)
- Tatsuya Haze (ORCID: https://orcid.org/0000-0001-8207-7025)
- Nobuhito Hirawa (ORCID: https://orcid.org/0000-0001-5824-3652)
- Kouichi Tamura (ORCID: https://orcid.org/0000-0002-0660-5372)
- Hiroaki Yasuzaki
- Sho Kinguchi (ORCID: https://orcid.org/0009-0007-0952-8548)
- Kei Terayama (ORCID: https://orcid.org/0000-0003-3914-248X)
- Yusuke Kobayashi (ORCID: https://orcid.org/0000-0002-4541-8318)
- Naoki Fujiwara (ORCID: https://orcid.org/0000-0003-2858-6878)
- Takashi Isozaki (ORCID: https://orcid.org/0009-0000-5697-7409)
- Yuki Murakami (ORCID: https://orcid.org/0009-0003-7265-4708)
Institutions
- Yokohama City University Medical Center (JP)
- Juntendo University (JP)
- Yokohama City University Hospital (JP)
- Naval Hospital Yokosuka Japan (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- BMC Medical Informatics and Decision Making
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12911-025-03034-3
- Citations
- 4
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 4.80
Funders
- Kanagawa Institute of Industrial Science and Technology