Glymphatic function associates with Alzheimer’s disease—signature region volumes, plasma biomarkers and white matter hyperintensity progression in cognitively unimpaired older adults
Worse glymphatic system function indicates decreased AD-signature region volumes, severe WMH lesions, elevated plasma ptau, and accelerated WMH progression before the occurrence of objective cognitive impairment. Therapeutic methods targeting the glymphatic system may prevent cognitive decline through the clearance of AD pathological proteins and the deceleration of WMH lesions.
Authors
- Futao Chen
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9061-6930)
- Lei Yan (ORCID: https://orcid.org/0000-0001-6850-5273)
- Jiaming Lu (ORCID: https://orcid.org/0009-0001-6888-8849)
- Pin Lv (ORCID: https://orcid.org/0000-0002-3425-9913)
- Yijun Bai
- Bing Zhang (ORCID: https://orcid.org/0000-0002-3953-0290)
- Qian Chen (ORCID: https://orcid.org/0000-0002-3585-305X)
- Cong Long
- Dongming Liu (ORCID: https://orcid.org/0000-0002-8203-8162)
- Xinru Xu (ORCID: https://orcid.org/0000-0001-8807-7691)
- Yajing Zhu (ORCID: https://orcid.org/0000-0001-8837-7387)
- Danni Ge
- Shunshun Du
Institutions
- Nanjing Drum Tower Hospital (CN)
- Imaging Center (US)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1093/ageing/afaf141
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- National Natural Science Foundation of China