CD163+ macrophages drive rapid pulmonary fibrosis via osteopontin secretion
CD163<sup>+</sup> macrophages are enriched in rapid pulmonary fibrosis patients and the mouse model, facilitating disease progression through the secretion of OPN. The CD163<sup>+</sup> macrophage-OPN axis could be a potential therapeutic target for rapid pulmonary fibrosis.
Authors
- Ruiting Lin
- Xianjie Chen (ORCID: https://orcid.org/0000-0001-8206-0557)
- Jun Zhong (ORCID: https://orcid.org/0000-0003-3148-4143)
- Sen Ye (ORCID: https://orcid.org/0000-0002-2303-7733)
- Suihui Deng
- Xiaodan Wu (ORCID: https://orcid.org/0000-0001-6289-1644)
- Zhenyuan Xu (ORCID: https://orcid.org/0000-0002-6124-2543)
- Chun Li (ORCID: https://orcid.org/0000-0002-8190-9843)
- Zhiping Wang
- Hui Li (ORCID: https://orcid.org/0000-0002-8438-0287)
- Ding Wenjun
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1016/j.intimp.2025.114976
- Citations
- 2
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Natural Science Foundation of China