Sex-specific differences in preclinical models of advanced chronic liver disease and portal hypertension
This study highlights sex-dependent molecular differences in the pathophysiology of cirrhosis in two preclinical models. Further research in preclinical and human liver disease is essential to develop safe and effective treatments for ACLD in both sexes.
Authors
- María Andrés‐Rozas (ORCID: https://orcid.org/0000-0002-0867-7775)
- Jordi Gracia‐Sancho (ORCID: https://orcid.org/0000-0001-7736-4089)
- David Al‐Adra (ORCID: https://orcid.org/0000-0002-4469-6375)
- Zoe Boyer‐Díaz (ORCID: https://orcid.org/0000-0002-7290-0484)
- Peio Aristu-Zabalza (ORCID: https://orcid.org/0000-0003-2911-7870)
- Douglas Maya‐Miles
- Sergi Guixé‐Muntet (ORCID: https://orcid.org/0000-0002-5748-1074)
- Anabel Fernández-Iglesias
Institutions
- University of Wisconsin–Madison (US)
- Departament de Salut (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Fisher Bioservices (United States) (US)
- Hospital Universitario Virgen del Rocío (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s13293-025-00721-8
- Citations
- 6
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 7.93
Funders
- European Commission
- Generalitat de Catalunya
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III