TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis
This study identifies the novel regulatory mechanism of the TGF-β/JNK signaling axis in MDBs formation, delivering mechanistic insights into MDB-associated chronic liver disease. Inhibition of JNK pathway suppresses MDBs formation while alleviates the inflammatory microenvironment by attenuating mitochondrial damage. Blocking the TGF-β/JNK signaling axis may represent a potential therapeutic strategy for MDB-associated chronic liver disease.
Authors
- Samuel W. French (ORCID: https://orcid.org/0000-0002-7611-881X)
- Jingjie Zhao (ORCID: https://orcid.org/0000-0002-1582-2053)
- Yi Shi (ORCID: https://orcid.org/0000-0002-2761-8324)
- Hui Liu (ORCID: https://orcid.org/0000-0002-3770-7902)
- Maoping Huang
- Wanmei Zhou (ORCID: https://orcid.org/0000-0002-4931-8744)
- Yi Zhao (ORCID: https://orcid.org/0000-0002-8522-8906)
- Xiaoping Tang (ORCID: https://orcid.org/0000-0001-8795-4293)
- Bei Zhong
Institutions
- UCLA Medical Center (US)
- Xiyuan Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Eighth People's Hospital (CN)
- Harbor–UCLA Medical Center (US)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s12967-025-06618-9
- Citations
- 1
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 1.40