MiR-383-5p promotes schistosomiasis-induced liver fibrosis by targeting peroxiredoxin-3
Our findings suggest that downregulating miR-383-5p after schistosome infection may alleviate liver inflammation by de-repressing PRDX3, thereby increasing ROS scavenging and reducing oxidative stress. This study elucidates the role of the miR-383-5p/PRDX3 axis in schistosomiasis-induced liver fibrosis, suggesting that PRDX3 is a potential therapeutic target for this disease.
Authors
- Chuanxin Yu
- Panpan Dong (ORCID: https://orcid.org/0000-0002-2231-9608)
- Congjin Mei
- Xinyue Zhang (ORCID: https://orcid.org/0000-0002-2880-3054)
- Jianfeng Zhang (ORCID: https://orcid.org/0000-0002-2870-1146)
- Yixin Li (ORCID: https://orcid.org/0000-0003-0733-9237)
- Chunrong Xiong
- Yingying Yang (ORCID: https://orcid.org/0000-0001-6779-080X)
- Li-Jun Song (ORCID: https://orcid.org/0000-0002-3897-5925)
- Kun Yang (ORCID: https://orcid.org/0009-0004-2373-360X)
- Ju-Lu Lu
Institutions
- Jiangsu Institute of Parasitic Diseases (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s13071-025-06824-w
- Citations
- 1
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province