Advantages of Incomplete Digestion in Human Hair Shaft Proteomics, a Focus on Cuticular Keratins
We developed a facile and robust sample preparation strategy for human hair shafts. The improved sequence coverage in cuticular keratins by shortened and incomplete proteolysis is critical for the identification of genetically variant peptides in keratins.
Authors
- Huu M. Tran
- Bingyun Sun (ORCID: https://orcid.org/0000-0002-4132-6942)
- D. Yee
- Phonchawit Kiatthitinan
Institutions
- Simon Fraser University (CA)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1002/rcm.10071
- Citations
- 1
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- Canada Foundation for Innovation
- Natural Sciences and Engineering Research Council of Canada
- British Columbia Knowledge Development Fund