Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism
Reprogrammed hepatic PRL signaling pathway with concomitant dysregulated lipid metabolism homeostasis was the causative mechanism of fatty liver under SJL, which was mediated through derailed serum PRL rhythm. Restoration of PRL rhythm could effectively alleviate SJL-induced fatty liver, providing new insight into treating MASLD.
Authors
- Yayuan Li
- Yan Bi (ORCID: https://orcid.org/0000-0003-3914-7854)
- Yinghuan Shi (ORCID: https://orcid.org/0000-0003-4534-7318)
- Hongli Yin (ORCID: https://orcid.org/0000-0002-2043-5066)
- Tianyu Wu (ORCID: https://orcid.org/0000-0002-5574-423X)
- Yu-Xin Guo
- Peihong Zhang
- Ye Zhu (ORCID: https://orcid.org/0000-0002-9687-3089)
- Jianping Jiang (ORCID: https://orcid.org/0000-0003-1120-6883)
Institutions
- Nanjing University of Information Science and Technology (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1186/s40779-025-00609-z
- Citations
- 5
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 4.57
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation