Functional outcomes in rectal cancer patients treated with immunotherapy and neoadjuvant therapy: a retrospective analysis
SCRT-CIT combined with surgery is associated with a significantly higher risk of bowel dysfunction, male erectile dysfunction, reduced sexual duration, and female sexual impairments, including dyspareunia and diminished sexual satisfaction. These findings underscore the importance of comprehensive functional assessments and individualized management for patients undergoing SCRT-CIT for locally advanced low rectal cancer.
Authors
- Zilong Wu (ORCID: https://orcid.org/0000-0003-3556-1943)
- Wei Li (ORCID: https://orcid.org/0000-0003-4991-0550)
- Yisong Gao
- Kaixiong Tao (ORCID: https://orcid.org/0000-0002-7723-6121)
- Gan Mao
- Tianyu Song (ORCID: https://orcid.org/0000-0001-9834-6795)
- Ruizhi Zhang (ORCID: https://orcid.org/0009-0006-8365-0966)
- Tao Zhang (ORCID: https://orcid.org/0000-0001-9331-8832)
- Li Xu (ORCID: https://orcid.org/0000-0001-6875-9396)
- Chong Li (ORCID: https://orcid.org/0009-0009-1230-2528)
- Zhenyu Lin (ORCID: https://orcid.org/0000-0002-1733-5806)
- Suao Liu
- Wenxiang Nie
Institutions
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Langenbeck s Archives of Surgery
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1007/s00423-025-03746-0
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China