Super-resolution sodium MRI of human gliomas at 3T using physics-based generative artificial intelligence
ATHENA generates high-resolution synthetic-sodium MRI at 3T, enabling clinically attainable multinuclear imaging for brain tumors that retain the inherent information from the native sodium. The resulting synthetic sodium significantly correlates with tissue expression, potentially supporting its utility as a non-invasive marker of underlying sodium homeostasis in brain tumors.
Authors
- Noriko Salamon (ORCID: https://orcid.org/0000-0002-3520-9467)
- Richard G. Everson (ORCID: https://orcid.org/0000-0003-2809-3061)
- Benjamin M. Ellingson (ORCID: https://orcid.org/0000-0002-2764-6640)
- Thorsten Feiweier (ORCID: https://orcid.org/0009-0005-3537-9844)
- Jingwen Yao (ORCID: https://orcid.org/0000-0002-8828-1841)
- Xiaodong Zhong (ORCID: https://orcid.org/0000-0001-8355-5279)
- Francesco Sanvito (ORCID: https://orcid.org/0000-0003-3379-9958)
- Alfredo L. Lopez Kolkovsky (ORCID: https://orcid.org/0000-0002-9375-1465)
- Bryan Clifford (ORCID: https://orcid.org/0000-0002-1966-0581)
- Nicholas S. Cho (ORCID: https://orcid.org/0000-0002-8686-0575)
- Timothy F. Cloughesy (ORCID: https://orcid.org/0000-0002-8656-7483)
- Sonoko Oshima (ORCID: https://orcid.org/0000-0002-1453-3807)
- Linda M. Liau (ORCID: https://orcid.org/0000-0002-4053-0052)
- Catalina Raymond (ORCID: https://orcid.org/0000-0003-2757-439X)
- Kunal Patel (ORCID: https://orcid.org/0000-0002-9854-9178)
- Heiko Meyer (ORCID: https://orcid.org/0000-0002-2631-1910)
- Fei Han
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of California, Los Angeles (US)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- CEA Paris-Saclay (FR)
- Siemens (United States) (US)
- Samueli Institute (US)
- Siemens Healthineers (Germany) (DE)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1007/s11060-025-05094-x
- Citations
- 2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Siemens Healthineers
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences
- Congressionally Directed Medical Research Programs