Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP
Overall, these studies identify overexpression of CHIP, which triggers ubiquitination and proteasomal degradation of nNOS in the PVN results in reduced inhibitory sympathetic tone in CHF.
Authors
- Kenichi Katsurada (ORCID: https://orcid.org/0000-0002-0567-1458)
- Hong Zheng (ORCID: https://orcid.org/0000-0002-1660-3573)
- Tapan A. Patel (ORCID: https://orcid.org/0000-0002-0631-5412)
- Kaushik P. Patel (ORCID: https://orcid.org/0000-0002-4500-0819)
Institutions
- Jichi Medical University (JP)
- University of South Dakota (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1161/hypertensionaha.125.24896
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81