Combination therapy using intestinal organoids and their extracellular vesicles for inflammatory bowel disease complicated with osteoporosis
This study highlights the translational potential of intestinal organoids and their extracellular vesicles as a dual-action biologic therapy that alleviates intestinal inflammation and reverses bone loss in IBD-associated osteoporosis. The identification of functional miRNAs within IOEVs supports their development as minimally invasive, cell-free therapeutics for systemic complications in inflammatory disease.
Authors
- Long Bai (ORCID: https://orcid.org/0000-0002-4757-746X)
- Zhenglin Dong (ORCID: https://orcid.org/0000-0001-6798-134X)
- Shihao Sheng (ORCID: https://orcid.org/0000-0003-4624-1160)
- Yuxiao Lai (ORCID: https://orcid.org/0000-0002-8648-6595)
- Han Liu (ORCID: https://orcid.org/0000-0001-7555-5578)
- Jianhua Wang (ORCID: https://orcid.org/0000-0001-6831-9593)
- Ruiyang Li (ORCID: https://orcid.org/0000-0003-0329-4852)
- Xiao Chen (ORCID: https://orcid.org/0009-0001-4365-1503)
- Mingkai Wang (ORCID: https://orcid.org/0000-0002-2231-4866)
- Jie Gao (ORCID: https://orcid.org/0000-0002-5930-0353)
- Chongru He
- Xiuhui Wang (ORCID: https://orcid.org/0000-0002-6031-0380)
- Jiacan Su (ORCID: https://orcid.org/0000-0001-7080-263X)
Institutions
- Shanghai University (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Shanghai Institutes for Biological Sciences (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1016/j.jot.2025.05.008
- Citations
- 6
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 6.27