SEW2871 Attenuates Blood-Brain Barrier Damage and Neuropathological Outcomes Related to Cerebral Small Vessel Disease
Long-term treatment with SEW2871 mitigated BBB leakage and brain injury, improved CBF and cognitive impairment in the spontaneously hypertensive rat stroke-prone model of small vessel disease. SEW2871 is effective at all doses, while 1.0 mg/kg dose demonstrated exceptional protection against the neuropathological cascades associated with small vessel disease.
Authors
- Halima Akter (ORCID: https://orcid.org/0000-0002-4683-4225)
- Laurel O. Sillerud (ORCID: https://orcid.org/0000-0002-5115-4339)
- Michael Griego (ORCID: https://orcid.org/0000-0003-2127-3342)
- Yirong Yang (ORCID: https://orcid.org/0000-0003-2252-0245)
- H. Chen
- Bushra Shal (ORCID: https://orcid.org/0000-0003-4696-8781)
- Sean Maez
- Haoran Deng
- Carlos Pérez (ORCID: https://orcid.org/0000-0001-8425-1875)
- Yi Yang (ORCID: https://orcid.org/0000-0003-1493-2952)
- Joanna McChriston
Institutions
- University of New Mexico (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Stroke
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1161/strokeaha.124.050452
- Citations
- 2
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68