Population pharmacokinetics of weight-based compared with fixed dosing of CAP256V2LS, a broadly neutralizing antibody for HIV prevention in women
For women weighing 60-93 kg, a fixed-dose of 1200 mg of CAP256V2LS produced similar adverse events and pharmacokinetic profiles as weight-based dosing. The fixed dose reduced variability in the plasma concentrations and product wastage compared with weight-based dosing.
Authors
- Roberto Heredia‐Ortiz
- Nigel Garrett (ORCID: https://orcid.org/0000-0002-4530-234X)
- Richard A. Koup (ORCID: https://orcid.org/0000-0002-3090-7282)
- Kevin Carlton
- Penny L. Moore (ORCID: https://orcid.org/0000-0001-8719-4028)
- Lynn Morris (ORCID: https://orcid.org/0000-0003-3961-7828)
- Marothi Letsoalo
- Martin Béliveau
- Sandeep Narpala
- Mike Castro (ORCID: https://orcid.org/0000-0002-8045-1754)
- Leonid Serebryannyy (ORCID: https://orcid.org/0000-0003-0213-1779)
- Derseree Archary (ORCID: https://orcid.org/0000-0002-2216-2866)
- Quarraisha Abdool Karim (ORCID: https://orcid.org/0000-0002-0985-477X)
- Salim S. Abdool Karim (ORCID: https://orcid.org/0000-0002-4986-2133)
- Tanuja N. Gengiah (ORCID: https://orcid.org/0000-0002-3405-5128)
- Sharana Mahomed (ORCID: https://orcid.org/0009-0005-1449-160X)
- Jennifer Wang (ORCID: https://orcid.org/0000-0002-2556-9100)
- Farzana Osman
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- National Institutes of Health (US)
- University of the Witwatersrand (ZA)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Ta Solutions (China) (CN)
- National Institute of Allergy and Infectious Diseases (US)
- National Institute for Communicable Diseases
- Columbia University (US)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-06-03
- DOI
- https://doi.org/10.1093/jac/dkaf181
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Halozyme
- Leidos
- Department of Science and Innovation, South Africa
- South African Medical Research Council
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- European and Developing Countries Clinical Trials Partnership