ER stress-related mitochondrial protein-coding gene risk model and in vitro experiments unveil OMA1 as a novel prognostic and therapeutic biomarker for low-grade glioma
This study provides a novel prognostic model based on ERSMGs, offering novel insights into LGG progression and invasion. OMA1-mediated mitochondrial dysfunction and ER stress play critical roles in glioma cell growth and survival, representing potential therapeutic targets.
Authors
- Wei‐Cheng Huang (ORCID: https://orcid.org/0000-0003-4437-3530)
- Long Jiang (ORCID: https://orcid.org/0000-0002-1506-7385)
- Li Yang (ORCID: https://orcid.org/0000-0001-9098-694X)
- Junquan Wang (ORCID: https://orcid.org/0000-0002-1304-3697)
- Chaoying Qin (ORCID: https://orcid.org/0000-0002-4476-0533)
- Yabo Feng (ORCID: https://orcid.org/0000-0002-1825-9956)
Institutions
- Central South University (CN)
- Second People Hospital of Hunan (CN)
- Chenzhou First People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.lfs.2025.123773
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Natural Science Foundation of Hainan Province