Highlights of 2024: unleashing the power of NK cells—cancer's worst nightmare
In this article for the Highlights of 2024 Series, we discuss strategies to enhance NK cell-based cancer therapies. These include (1) cytokine expression on bacterial membranes to boost NK cell activation in tumors, (2) optimizing CAR-NK cell manufacturing for improved efficacy, (3) using CRISPR-Cas9 to identify and target inhibitory genes, and (4) using tetraspecific engagers to enhance cytotoxicity and cytokine memory-like NK cells strengthening anti-tumor responses. This year's progress holds much promise for cancer treatments exploiting NK cells.
Authors
- Fernando Souza-Fonseca-Guimarães (ORCID: https://orcid.org/0000-0002-2037-8946)
- Sylvie Lesage (ORCID: https://orcid.org/0000-0002-0968-2795)
- Capucine Bourel
Institutions
- Translational Research Institute (AU)
- The University of Queensland (AU)
- Hôpital Maisonneuve-Rosemont (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Immunology and Cell Biology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1111/imcb.70037
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Cancer Research Society
- PA Research Foundation
- Children's Hospital Foundation
- National Breast Cancer Foundation
- University of Queensland
- Tour de Cure
- Canadian Institutes of Health Research