Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques
A vaccine is considered essential for controlling the HIV pandemic and ultimately eradicating AIDS. Neutralizing antibodies and MHC-E-restricted CD8+ T cells have shown the ability to protect against the simian counterpart of HIV, SIV, in rhesus macaques. In this study, we provide preliminary evidence that combining these orthogonal antiviral mechanisms can offer increased protection against SIV. Specifically, the replication arrest observed following vaccination with a rhesus cytomegalovirus (RhCMV/SIV)-based vaccine was enhanced by the presence of a passively administered neutralizing antibody at incompletely protective levels. This report encourages studies involving larger cohorts of macaques and alternative methods for administering neutralizing antibodies.
Authors
- David Morrow (ORCID: https://orcid.org/0000-0003-4686-830X)
- Raiza Bastidas
- Randy Fast (ORCID: https://orcid.org/0000-0003-3042-9214)
- Jessica Coppola (ORCID: https://orcid.org/0000-0002-7574-996X)
- Karen Saye
- Aaron Barber-Axthelm
- Joseph G. Jardine (ORCID: https://orcid.org/0000-0001-8951-1074)
- Rebecca Shoemaker
- Mara Parren (ORCID: https://orcid.org/0000-0003-0067-0154)
- Dennis R. Burton (ORCID: https://orcid.org/0000-0001-6711-9864)
- Scott G. Hansen (ORCID: https://orcid.org/0000-0002-9845-6481)
- Roxanne M. Gilbride (ORCID: https://orcid.org/0000-0001-6040-104X)
- Kelli Oswald (ORCID: https://orcid.org/0000-0003-2327-8497)
- Rachele M. Bochart (ORCID: https://orcid.org/0000-0001-9795-6516)
- Louis J. Picker (ORCID: https://orcid.org/0000-0003-0546-398X)
- Jacqueline Malvin
- Jeffrey D. Lifson
- Sohita Ojha (ORCID: https://orcid.org/0009-0008-4473-7078)
- Shana Feltham (ORCID: https://orcid.org/0009-0004-5862-5860)
Institutions
- Oregon National Primate Research Center (US)
- Leidos (United States) (US)
- International AIDS Vaccine Initiative (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3389/fmicb.2025.1592647
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Bill and Melinda Gates Foundation
- Oregon Health and Science University
- James B. Pendleton Charitable Trust
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases