Nonlinear relationship between lumbar bone mineral density and high-density lipoprotein cholesterol in patients with type 2 diabetes
The independent nonlinear, J-shaped association between lumbar BMD and serum HDL-C in T2DM patients was detected in this study, with FBG negatively mediating this relationship. These findings prove the effect of lipid metabolism and glucose dysregulation on bone health and contribute to the development of osteoporosis prevention and treatment strategies for T2DM patients.
Authors
- Changhua Liang
- Meilan Xue (ORCID: https://orcid.org/0000-0002-7296-0778)
- Fangfang Guo (ORCID: https://orcid.org/0000-0003-4245-998X)
- Yangyang Chen (ORCID: https://orcid.org/0009-0006-3864-1040)
- Sujuan Liu (ORCID: https://orcid.org/0009-0000-2587-5987)
- Shi-Li Gu
- HE Yu-hua
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3389/fendo.2025.1570841
- Citations
- 1
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Xinxiang Medical University