Preliminary study on the time-correlation changes in brain neurotransmitters of mice exposed to mushroom toxin ibotenic acid
Preliminary studies have demonstrated that acute exposure to ibotenic acid inhibits motor activity but does not significantly affect learning and memory in mice. Exposure to ibotenic acid induces alterations in GABA/Glutamic-Acid, dopaminergic, serotonergic, and neurotransmitters associated with the cholinergic system in the brains of mice, with the most pronounced changes occurring in the brain stem region, exhibiting time-dependent and region-specific effects. This study offers new insights into the neurotoxic mechanisms of ibotenic acid.
Authors
- Xian Zhou (ORCID: https://orcid.org/0000-0001-8766-8158)
- Ruanxian Dai (ORCID: https://orcid.org/0009-0005-0169-8580)
- Qiang Meng (ORCID: https://orcid.org/0000-0002-5741-0719)
- H K. Song
- Guobing Chen
- Zhantao Duan
- Li Ma (ORCID: https://orcid.org/0000-0001-5847-2375)
- Zhen Shi
- Fuping Wang (ORCID: https://orcid.org/0000-0003-0009-9138)
Institutions
- Kunming University of Science and Technology (CN)
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3389/fnins.2025.1561291
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kunming Medical University
- Yunnan Provincial Science and Technology Department