Exploring the unseen: Side effects of isotretinoin on the perianal and perigenital regions

Acne vulgaris is a common chronic skin condition affecting a large portion of the population. Isotretinoin is considered the most effective treatment, offering unparalleled results, including scar reduction. Most of its side effects stem from hypervitaminosis A, leading to mucosal and skin dryness. The most commonly reported adverse effects include dry lips and skin. However, perianal and perigenital side effects are often overlooked in studies, despite their notable prevalence — up to 26% for perianal symptoms and 40% for perigenital symptoms. This review highlights these underrecognized adverse effects, aiming to promote awareness and encourage open discussions between healthcare providers and patients.