Determination of pKA of nonvolatile weak acids in plasma of healthy volunteers and critically ill patients
Our findings confirm stable pK<sub>A</sub> and A<sub>TOT</sub>/TP values in human plasma in both health and disease, supporting the Staempfli-Constable model for clinical acid-base diagnostics. Unexplained anions in sepsis are attributed to low molecular weight strong ions rather than alterations in plasma protein dissociation.
Authors
- Victor van Bochove
- Alberto Zanella (ORCID: https://orcid.org/0000-0002-2967-2527)
- Francesco Zadek (ORCID: https://orcid.org/0000-0002-2377-3992)
- Thomas Länger (ORCID: https://orcid.org/0000-0002-9725-8520)
- Petr Waldauf (ORCID: https://orcid.org/0000-0003-4668-5837)
- František Duška (ORCID: https://orcid.org/0000-0003-1559-4078)
- Paul Elbers (ORCID: https://orcid.org/0000-0003-0447-6893)
- Serena Brusatori
- Martin Krbec (ORCID: https://orcid.org/0000-0003-2692-6904)
Institutions
- University of Milan (IT)
- Charles University (CZ)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s40635-025-00762-8
- Citations
- 1
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Univerzita Karlova v Praze
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico