An Electrospun DFO-Loaded Microsphere/SAIB System Orchestrates Angiogenesis–Osteogenesis Coupling via HIF-1α Activation for Vascularized Bone Regeneration
The DFO-MS@SAIB system promotes bone regeneration via sustained deferoxamine release and HIF-1α-mediated signaling. Its angiogenesis-osteogenesis coupling effect facilitates vascularized bone regeneration, thereby offering a translatable strategy for critical-sized bone-defect repair.
Authors
- Xiaoyan Yuan (ORCID: https://orcid.org/0000-0002-7210-2407)
- Xujia Shan
- Xiaohong Wu (ORCID: https://orcid.org/0000-0003-0894-3962)
Institutions
- Chongqing Medical University (CN)
Publication Details
- Journal
- Polymers
- Published
- 2025-05-31
- DOI
- https://doi.org/10.3390/polym17111538
- Citations
- 4
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Natural Science Foundation of China