Assessing COVID IGRA and IgG antibodies in healthcare workers post vaccination

Generally, no correlation was established between humoral and CMI responses following COVID-19 vaccination. That only 83.3% and 45.2% among the Pfizer-vaccinated HCWs tested positive for COVID humoral and CMI, respectively, prevents substantial conclusions about test reliability for determining immunity status post vaccination. Whether these results are influenced by the specific antigenic epitopes used in the tests or by the potential deterioration of the immune response over time remains to be determined. The incongruity between humoral and CMI responses post-vaccination suggests the need for more comprehensive testing methodologies to assess post-vaccination immunity.