Subcutaneous Allergen Immunotherapy With Hypoallergenic Bet v 1 Compared to Conventional Extract: Poorer Blocking Antibody Capacity Dominated by <scp> IgG <sub>1</sub> </scp> Instead of <scp> IgG <sub>4</sub> </scp>
Preclinically established hypoallergenicity of BM41 did not result in a lower number of adverse events. The reduced induction of sIgG<sub>4</sub> by the fold variant in the course of the treatment was less efficient in blocking sIgE-mediated responses. This is the first study providing evidence that, instead of a Th1-favored IgG<sub>1</sub>-dominated response, "modified Th2"-skewed IgG<sub>4</sub>-dominated humoral responses are beneficial in AIT vaccine design.
Authors
- Lars K. Poulsen (ORCID: https://orcid.org/0000-0002-1730-847X)
- Lorenz Aglas (ORCID: https://orcid.org/0000-0002-1236-5934)
- Lars Blom (ORCID: https://orcid.org/0000-0003-2027-727X)
- Frank Stolz (ORCID: https://orcid.org/0000-0001-6878-6239)
- Mario Wenger (ORCID: https://orcid.org/0000-0002-7893-1935)
- Scott A. Smith (ORCID: https://orcid.org/0000-0002-5519-8662)
- Ewa A. Bartko (ORCID: https://orcid.org/0000-0002-1567-3350)
- Ronald van Ree (ORCID: https://orcid.org/0000-0003-0767-0894)
- Laurian Zuidmeer (ORCID: https://orcid.org/0000-0003-3245-5555)
- Fátima Ferreira (ORCID: https://orcid.org/0000-0003-0989-2335)
- Carsten Bindslev‐Jensen (ORCID: https://orcid.org/0000-0002-8940-038X)
- Amin Kraiem (ORCID: https://orcid.org/0000-0003-3792-0487)
- Serge A. Versteeg (ORCID: https://orcid.org/0000-0002-9729-3000)
- Line Kring Tannert (ORCID: https://orcid.org/0000-0003-4039-5708)
- Natália Nunes (ORCID: https://orcid.org/0000-0002-7247-4745)
- Hannah Widauer (ORCID: https://orcid.org/0000-0003-0593-7567)
- Angela Neubauer
- Sibile Sinkunaite
Institutions
- University of Copenhagen (DK)
- University of Salzburg (AT)
- Odense University Hospital (DK)
- Gentofte Hospital (DK)
- Biomay (Austria) (AT)
- Amsterdam University Medical Centers (NL)
- Medical University of Vienna (AT)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Allergy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1111/all.16606
- Citations
- 3
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 4.87
Funders
- European Commission
- Universität Salzburg