SEPSIS-INDUCED MYOCARDIAL DYSFUNCTION: WHAT IS KNOWN? (LITERATURE REVIEW)

Sepsis is defi ned as a life-threatening organ dysfunction caused by an unregulated response to infection. Sepsis- induced myocardial dysfunction is a common and serious complication in patients with generalized infectious and infl ammatory processes. Due to the lack of a broad consensus on the defi nition, the epidemiology of septic cardiomyopathy remains unclear. Disorders of the endothelium, metabolism, and immune response are usually involved in the pathogenesis of cardiovascular dysfunction. However, the point of transition from a protective to an unfavorable and maladaptive process is the absence of a humoral response in sepsis.The purpose – to summarize the available knowledge about the pathogenesis, modern diagnostic tools and biomarkers of sepsis- induced myocardial dysfunction.Conclusions. Thus, sepsis- induced myocardial dysfunction remains a threatening component of multiorgan incompatibility against the background of the septic process, which increases the risk of its lethality, and only the complex use of clinical and paraclinical methods allows for timely verifi cation of the development of cardiovascular disorders in sepsis for the purpose of their timely correction and personalized treatment approach.