COLON MICROBIOME IN MODERATE AND SEVERE COVID-19 DISEASE

Objective of the study – to investigate and analyze the human colonic microbiome in moderate and severe COVID-19.Material and methods. Microbiological (bacteriological and mycological) examination of clinical material (stool) was performed in 20 patients with moderate and 24 patients with severe community- acquired pneumonia. Among the study participants with moderate COVID-19, there were 60 % (12) women and 40 % (8) men, and 50 % (12) women and 50 % (12) men with severe COVID-19. The average age of the study participants with moderate COVID-19 was 48.70±9.32 years (32 to 63 years), and with severe COVID-19-52.58±7.30 years. Clinical material (the last portion of fresh feces) was collected with a sterile spatula and placed in sterile pharmacy vials. Isolation and identifi cation of isolated pure cultures were performed according to generally accepted methods.Results. It has been found that the quantitative dominance of the taxa of the colon microbiota of patients with moderate COVID-19 is as follows: the highest level of dominance was found in common E. coli (129.06 cfu), lower levels in the following taxa: Bifi dobacterium (19.34 % lower) > bacteria of the genus Lactobacillus (75.97 %) > bacteria of the genus Staphylococcus (2.07 times) > E. coli Lac (2.26 times) of the genus Candida (2.54 times) > E. coli with altered properties (2.67 times) > bacteria of the genera Proteus, Enterobacter, Asinobacter (7.04 times) > Klebsiella, Citrobacter (7.62 times).