Two unique cases of eosinophilic granulomatosis with polyangiitis in childhood treated with anti-interleukin-5 therapy: infantile-onset and submandibular salivary gland involvement
To our knowledge, this is the first reported case of submandibular salivary gland infiltrate in a child with EGPA and the youngest successfully treated patient with EGPA reported in the literature. These cases demonstrate the variation in age and disease manifestations seen in children with EGPA as well as positive responses to anti-interleukin-5 therapy. Children with EGPA may present with common or unusual complaints and require astute recognition to avoid delays in diagnosis and long-term damage.
Authors
- Heather Hoch De Keyser (ORCID: https://orcid.org/0000-0002-4392-0996)
- Csaba Galambos (ORCID: https://orcid.org/0000-0002-8940-6650)
- Jason P. Weinman (ORCID: https://orcid.org/0000-0001-6540-3757)
- Jerimiah Lysinger
- Nicholas Willard (ORCID: https://orcid.org/0000-0003-4912-201X)
- Angus Toland
- Jared J. Abbott
- Jessica L. Bloom (ORCID: https://orcid.org/0000-0002-7645-2084)
- David Andrew Mong (ORCID: https://orcid.org/0000-0003-0279-0301)
- E. F. CONSTANTINE
- Adam M Bartholomeo (ORCID: https://orcid.org/0000-0002-0571-0357)
- Clara Lin (ORCID: https://orcid.org/0000-0002-5840-875X)
- Nicholas Paine Gilman
- Pia J. Hauk
- Inna Powers
Institutions
- University of Iowa (US)
- University of Colorado Anschutz Medical Campus (US)
- Billings Clinic (US)
Publication Details
- Journal
- Pediatric Rheumatology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12969-025-01115-1
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52