Methodological Approaches for Economic Comparison of Mesenchymal Stem Cell and Exosome-based Therapies with Conventional Endodontic Treatments in Regenerative Endodontics

Regenerative endodontics, particularly through mesenchymal stromal cell (MSC)- based and exosome-based therapies, presents innovative alternatives to traditional endodontic treatments. However, the economic feasibility of integrating these advanced therapies into Kazakhstan’s dental healthcare system has yet to be systematically analyzed. This methodological study aims to establish a framework for evaluating the cost-effectiveness of regenerative therapies compared to conventional endodontic methods. It focuses on identifying the economic factors that influence the potential adoption of these therapies in Kazakhstan. The study outlines a comprehensive methodology for comparing the costs and potential long-term benefits of MSC- and exosome-based therapies. Data were collected from clinical studies, healthcare providers, and literature on cost factors such as treatment expenses, retreatment rates, and complication management.