RESPIRATORY DISORDERS IN NEWBORNS WITH EARLY NEONATAL SEPSIS

The objective of study – to examine the clinical manifestations of sepsis- inducedrespiratory disorders in newborns within the fi rst two days of life who exhibited indicationsof early neonatal infection.Material and methods. A comprehensive complex examination was conducted on100 newborns. Two clinical groups were established. Group I comprised 36 newbornswith confi rmed early neonatal infection (66.7 % male, 50.6 % residing in urban areas),while the second comparison group (Group II) included 64 children in whom the presenceof early neonatal infection was simplifi ed (50.0 % male, 48.4 % residing in urban areas).According to the primary clinical characteristics, the groups were found to be comparable.Results. The studies demonstrated that children in clinical group I exhibited a signifi cantlyhigher prevalence (P<0,01) of clinical sings of respiratory distress, including dyspnoea,apnoea, tachypnoea and involvement of additional muscles in the act of breathing.Furthermore, it was determined that infants with low gestational age exhibited a 2.23-foldincreased likelihood of early neonatal sepsis and a 1.30-fold elevated risk of bronchopulmonarydysplasia. The evaluation of the clinical and epidemiological risk of a generalised infectiousand infl ammatory process in the fi rst two days of life in newborns with signs of acuterespiratory distress enabled us to ascertain that the risk of early neonatal sepsis was elevatedwhen dyspnoea and apnoea were observed (odds ratio 30.7), tachypnoea and chest retraction(odds ratio 6.25), as well as nasal fl aring and exhaling wheezing (odds ratio 12.03).Conclusion. Early neonatal sepsis was accompanied by distinct indicators of respiratorydistress, most often associated with low gestational age.