Safety and efficacy of platelet-rich plasma in the treatment of periorbital skin photoaging

Periorbital skin photoaging is a common cosmetic problem.Presently, conventional treatment methods cannot achieve satisfactory results. Periorbital skin aging may benefit from platelet-rich plasma (PRP) injection. However, there is little experimental evidence on the safety and efficacy of PRP in the treatment of periorbital skin photoaging. To examine the safety and efficacy of PRP injection in the treatment of periorbital skin photoaging, PRP was injected into the periorbital skin of 20 patients, and patient satisfaction was assessed at the first month (M1), the second month (M2), and the third month (M3) after treatment. Two experienced dermatologists independently evaluated the patient's skin before and after treatment according to internationally accepted guidelines. The objective indicators of skin hydration, melanin index, erythema index, skin brightness, transepidermal water loss (TEWL), skin elasticity, and skin thickness were measured. Some subjective indicators, including pigmentation around the eyes, suborbital wrinkles, and static crow's feet, were significantly improved. Some objective indicators, including skin brightness, skin thickness, and collagen strength, were also significantly improved. Eye bags and TEWL slightly improved, but the differences were not statistically significant. The overall patient satisfaction with the treatment was high, no serious complications were noted, and the recovery profile was favorable. PRP injection was safe and effective for the treatment of periorbital skin photoaging.