Case Study on a Multi-Layer Approach to Skin Rejuvenation: Effects of Energy-Based Devices and Injectable Biostimulatory Therapies

Achieving smooth, healthy-looking skin is a common aesthetic goal across all age groups. This study assessed the effectiveness of a novel protocol combining non-crosslinked hyaluronic acid (HA), hydro-exfoliation, infrared technology and non-ablative fractional 1470 nm laser to enhance skin quality parameters. This case report included participants aged 43 and 58 years, both in good general health but exhibiting signs of skin atrophy or aging in the face or neck area. On Day 0, subjects underwent mesotherapy injections with non-crosslinked HA (18 mg/mL), supplemented with 0.01% calcium hydroxyapatite, glycine, and l-proline, administered at depths of 0.5 to 4 mm. On Day 7, a hydro-exfoliation and infrared treatment was performed, followed by a session with a non-ablative fractional 1470 nm laser. Skin quality improvements were visually assessed through comparative photographic analysis taken before treatment and four weeks post-procedure. The comparison revealed enhancements in wrinkle reduction, pore size, skin texture, and overall firmness. All treatments were well tolerated. In conclusion, the combination of non-crosslinked HA mesotherapy, hydro-exfoliation, infrared technology, and non-ablative fractional laser led to noticeable improvements in multiple skin quality parameters across a broad age range. While the study highlights the cosmetic benefits of this approach, further research is needed to comprehensively evaluate the long-term safety profile of these treatments, as the current methodology was not specifically designed for safety assessment.