Point-of-Care Monitoring for Lung Cancer from Exhaled Breath Formaldehyde via Luminescent Metal–Organic Frameworks

The identification of specific markers in exhaled gas from individuals with lung cancer has significantly enhanced the feasibility of early lung cancer screening. This paper presents the synthesis of a 2D Cu-BDC-N<sub>2</sub>H<sub>3</sub> nanosheet at room temperature, which has been applied for the noninvasive diagnosis and point-of-care test (POCT) of lung cancer. During this approach, the hydrazine group in the ligand molecule was employed to enhance the intrinsic fluorescence of Cu-BDC-N<sub>2</sub>H<sub>3</sub> through a Schiff base reaction with formaldehyde (HCHO), thereby reducing the detection limits of HCHO gas and aqueous solution (25 ppb and 0.316 μM). As a proof of concept, Cu-BDC-N<sub>2</sub>H<sub>3</sub> was successfully applied to the early screening of lung cancer patients with an accuracy of 97.45%. The results indicate that the established breath analysis method provides a viable alternative for lung cancer screening.

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Publication Details

Journal
ACS Sensors
Published
2025-06-02
DOI
https://doi.org/10.1021/acssensors.5c00476
Citations
5
Primary Topic
Advanced Chemical Sensor Technologies
Type
article
Field-Weighted Citation Impact
3.37

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article

Point-of-Care Monitoring for Lung Cancer from Exhaled Breath Formaldehyde via Luminescent Metal–Organic Frameworks

Yue Niu, You Wang, Chao Ma, Yiquan Xiong et al.
5 citations
ACS Sensors
Advanced Chemical Sensor Technologies
3.37
article

Point-of-Care Monitoring for Lung Cancer from Exhaled Breath Formaldehyde via Luminescent Metal–Organic Frameworks

Yue Niu, You Wang, Chao Ma, Yiquan Xiong, Zhen Zhang, Junwei Zeng, Yun-Liang Yu, Chengcheng Shi, Chen Sun, Zhenhua Gao, Hu Chen, Hai Xu, Qingtao Xu
article en
5 citations

Abstract

The identification of specific markers in exhaled gas from individuals with lung cancer has significantly enhanced the feasibility of early lung cancer screening. This paper presents the synthesis of a 2D Cu-BDC-N<sub>2</sub>H<sub>3</sub> nanosheet at room temperature, which has been applied for the noninvasive diagnosis and point-of-care test (POCT) of lung cancer. During this approach, the hydrazine group in the ligand molecule was employed to enhance the intrinsic fluorescence of Cu-BDC-N<sub>2</sub>H<sub>3</sub> through a Schiff base reaction with formaldehyde (HCHO), thereby reducing the detection limits of HCHO gas and aqueous solution (25 ppb and 0.316 μM). As a proof of concept, Cu-BDC-N<sub>2</sub>H<sub>3</sub> was successfully applied to the early screening of lung cancer patients with an accuracy of 97.45%. The results indicate that the established breath analysis method provides a viable alternative for lung cancer screening.

ACS SensorsVol. 10(6)
Harbin Medical University (CN), South China Normal University (CN), Harbin Institute of Technology (CN), Dongguan University of Technology (CN), Physical Sciences (United States) (US), Brazilian National Association of Graduate Programs in Communication (BR), Centre of Excellence for Advanced Materials (CN), Great Bay University
National Natural Science Foundation of China
Openalex Percentile: Top 8%
Advanced Chemical Sensor Technologies
3.37
DOISourceOpenAlex
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