Newly Isolated Aromatic Compounds from <i>Ailanthus altissima</i> and Their Anti-inflammatory Activity
Five newly isolated aromatic natural products were isolated from the bark of Ailanthus altissima. These include two benzoic derivatives (<b>1</b> and <b>2</b>), a benzoquinone analogue (<b>3</b>), and a pair of lignan enantiomers [(±)-<b>4</b>]. The structures of these compounds were elucidated unambiguously through spectral evidence and chemical calculations. Notably, compound <b>3</b> exhibited significant anti-inflammatory effects both <i>in vitro</i> and <i>in vivo</i>, as it reduced the secretion of proinflammatory factors at a concentration of 15 μM. Results from Western blotting, in conjunction with molecular dynamics analysis, indicate that the inhibition of NF-κB signaling pathways may partially explain the anti-inflammatory activity of compound <b>3</b>.
Authors
- Da‐Le Guo (ORCID: https://orcid.org/0000-0003-3219-7066)
- Yun-Jie Hu
- Zhuohong Li (ORCID: https://orcid.org/0000-0002-8915-4481)
- De-Feng Peng
- Bin Guo (ORCID: https://orcid.org/0000-0002-2764-1137)
- Sining Li (ORCID: https://orcid.org/0000-0001-5260-4015)
- Yun Deng (ORCID: https://orcid.org/0000-0002-3428-8992)
- Huimin Zhang (ORCID: https://orcid.org/0000-0003-2636-7858)
- Yulong Li (ORCID: https://orcid.org/0000-0003-4836-843X)
- W. L. Dong (ORCID: https://orcid.org/0000-0001-9391-6154)
- Li Huang (ORCID: https://orcid.org/0000-0003-3910-3982)
- Lingyun Zhao (ORCID: https://orcid.org/0000-0002-7055-2746)
- Guangjie Yang (ORCID: https://orcid.org/0000-0003-1783-4282)
- Congcong Li (ORCID: https://orcid.org/0000-0001-9713-0271)
Institutions
- Sichuan Entry-Exit Inspection and Quarantine Bureau (CN)
- Herman Miller (United States) (US)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1021/acsomega.5c00710
- Citations
- 2
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province